IFNγ-Induced MHC Class II Expression on Islet Endothelial Cells Is an Early Marker of Insulitis but Is Not Required for Diabetogenic CD4(+) T Cell Migration

Diabetogenic T cells infiltrate the pancreatic islets by transmigrating across the microcapillaries residing close to, or within, the pancreatic islets. Deficiency in IFNγ signaling prevents efficient migration of T cells into the pancreatic islets, but the IFNγ-regulated molecules that mediate this...

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Detalles Bibliográficos
Autores principales: Scott, Nicholas A., Zhao, Yuxing, Krishnamurthy, Balasubramanian, Mannering, Stuart I., Kay, Thomas W. H., Thomas, Helen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282031/
https://www.ncbi.nlm.nih.gov/pubmed/30555479
http://dx.doi.org/10.3389/fimmu.2018.02800

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282031/
https://www.ncbi.nlm.nih.gov/pubmed/30555479
http://dx.doi.org/10.3389/fimmu.2018.02800

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