Cargando…

IFNγ-Induced MHC Class II Expression on Islet Endothelial Cells Is an Early Marker of Insulitis but Is Not Required for Diabetogenic CD4(+) T Cell Migration

Diabetogenic T cells infiltrate the pancreatic islets by transmigrating across the microcapillaries residing close to, or within, the pancreatic islets. Deficiency in IFNγ signaling prevents efficient migration of T cells into the pancreatic islets, but the IFNγ-regulated molecules that mediate this...

Descripción completa

Detalles Bibliográficos
Autores principales:	Scott, Nicholas A., Zhao, Yuxing, Krishnamurthy, Balasubramanian, Mannering, Stuart I., Kay, Thomas W. H., Thomas, Helen E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282031/ https://www.ncbi.nlm.nih.gov/pubmed/30555479 http://dx.doi.org/10.3389/fimmu.2018.02800

Ejemplares similares

Blood leukocytes recapitulate diabetogenic peptide–MHC-II complexes displayed in the pancreatic islets
por: Vomund, Anthony N., et al.
Publicado: (2021)

Islet Amyloid Polypeptide Is a Target Antigen for Diabetogenic CD4(+) T Cells
por: Delong, Thomas, et al.
Publicado: (2011)

Pancreatic Islet Cells Response to IFNγ Relies on Their Spatial Location within an Islet
por: De Burghgrave, Marine, et al.
Publicado: (2022)

In Vivo Enrichment of Diabetogenic T Cells
por: Thelin, Martin A., et al.
Publicado: (2017)

Register shifting of an insulin peptide–MHC complex allows diabetogenic T cells to escape thymic deletion
por: Mohan, James F., et al.
Publicado: (2011)

Epigenetic regulations in the IFNγ signalling pathway: IFNγ-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes
por: Vlková, Veronika, et al.
Publicado: (2014)

Both IFN-γ and IL-4 Induce MHC Class II Expression at the Surface of Mouse Pro-B Cells
por: Lombard-Platet, Suzanne, et al.
Publicado: (1997)

IFN-γ-induced increase in the mobility of MHC class II compartments in astrocytes depends on intermediate filaments
por: Vardjan, Nina, et al.
Publicado: (2012)

Integrin β1 Optimizes Diabetogenic T Cell Migration and Function in the Pancreas
por: Espinosa-Carrasco, Gabriel, et al.
Publicado: (2018)

MHC Class II is Induced by IFNγ and Follows Three Distinct Patterns of Expression in Colorectal Cancer Organoids
por: Pickles, Oliver J., et al.
Publicado: (2023)

Inducible IFN-γ Expression for MHC-I Upregulation in Devil Facial Tumor Cells
por: Ong, Chrissie E. B., et al.
Publicado: (2019)

MHC-class-II are expressed in a subpopulation of human neural stem cells in vitro in an IFNγ–independent fashion and during development
por: Vagaska, B., et al.
Publicado: (2016)

Diabetogene Umweltfaktoren
por: Wabnitz, Katharina, et al.
Publicado: (2022)

Monitoring immunomodulation strategies in type 1 diabetes
por: Krishnamurthy, Balasubramanian, et al.
Publicado: (2023)

Intratumoral Hypoxia Reduces IFN-γ–Mediated Immunity and MHC Class I Induction in a Preclinical Tumor Model
por: Murthy, Aditi, et al.
Publicado: (2019)

IFNγ producing CD8(+) T cells modified to resist major immune checkpoints induce regression of MHC class I-deficient melanomas
por: Buferne, Michel, et al.
Publicado: (2015)

An Erk/Cdk5 axis controls the diabetogenic actions of PPARγ
por: Banks, Alexander S., et al.
Publicado: (2014)

Slc11a1 Enhances the Autoimmune Diabetogenic T-Cell Response by Altering Processing and Presentation of Pancreatic Islet Antigens
por: Dai, Yang D., et al.
Publicado: (2009)

IL-6-mediated MHC class II induction on RIN-5AH insulinoma cells by IFN-γ occurs via the G-protein pathway
por: Vassiliadis, S., et al.
Publicado: (1995)

Diabetogenic T-Cell Clones Recognize an Altered Peptide of Chromogranin A
por: Delong, Thomas, et al.
Publicado: (2012)

N-Octanoyl-Dopamine inhibits cytokine production in activated T-cells and diminishes MHC-class-II expression as well as adhesion molecules in IFNγ-stimulated endothelial cells
por: Hofmann, Björn B., et al.
Publicado: (2019)

Schistosoma japonicum Soluble Egg Antigens Attenuate IFN-γ-Induced MHC Class II Expression in RAW 264.7 Macrophages
por: Tang, Gui-Xia, et al.
Publicado: (2012)

Statin diabetogenicity: guidance for clinicians
por: Ray, Kausik
Publicado: (2013)

Insulin teaches a new lesson in tolerance
por: Kay, Thomas W H, et al.
Publicado: (2009)

Diabetogenic glucose and insulin concentrations modulate transcriptom and protein levels involved in tumour cell migration, adhesion and proliferation
por: Masur, K, et al.
Publicado: (2011)

Prevention of “Humanized” Diabetogenic CD8 T-Cell Responses in HLA-Transgenic NOD Mice by a Multipeptide Coupled-Cell Approach
por: Niens, Marijke, et al.
Publicado: (2011)

Epigenetic regulation of diabetogenic adipose morphology
por: Kerr, A.G., et al.
Publicado: (2019)

Recognition of Multiple Hybrid Insulin Peptides by a Single Highly Diabetogenic T-Cell Receptor
por: Parras, Daniel, et al.
Publicado: (2021)

Islet Dysfunction in a Novel Transgenic Model of T Cell Insulitis
por: Esakov, Emily, et al.
Publicado: (2021)

Matching for HLA-DR excluding diabetogenic HLA-DR3 and HLA-DR4 predicts insulin independence after pancreatic islet transplantation
por: Ballou, Cassandra, et al.
Publicado: (2023)

Human MHC class I molecule, HLA-A2.1, mediates activation of CD8(+) T cell IFN-γ production and the T cell-dependent protection against reactivation of cerebral Toxoplasma infection
por: Mani, Rajesh, et al.
Publicado: (2022)

Diabetogenic Potential of Ancestral and Modern Wheat Landraces
por: Aguayo-Patrón, Sandra V., et al.
Publicado: (2017)

Diabetogenic Effects of Ochratoxin A in Female Rats
por: Mor, Firdevs, et al.
Publicado: (2017)

Effective Control of Chronic γ-Herpesvirus Infection by Unconventional MHC Class Ia–Independent CD8 T Cells
por: Braaten, Douglas C, et al.
Publicado: (2006)

Interferon-γ Induces Expression of MHC Class II on Intestinal Epithelial Cells and Protects Mice from Colitis
por: Thelemann, Christoph, et al.
Publicado: (2014)

IFN-γ Mediates the Rejection of Haematopoietic Stem Cells in IFN-γR1-Deficient Hosts
por: Rottman, Martin, et al.
Publicado: (2008)

IFN-γ modulates Ly-49 receptors on NK cells in IFN-γ-induced pregnancy failure
por: Li, Zhong-Yin, et al.
Publicado: (2015)

Soluble FAS ligand is not required for pancreatic islet inflammation or beta-cell destruction in non-obese diabetic mice
por: Trivedi, Prerak M., et al.
Publicado: (2019)

Thymus dictates major histocompatibility complex (MHC) specificity and immune response gene phenotype of class II MHC-restricted T cells but not of class I MHC-restricted T cells
Publicado: (1984)

Emergence of NK1.1+ cells as effectors of IFN-gamma dependent immunity to Toxoplasma gondii in MHC class I-deficient mice
Publicado: (1993)

Cannot write session to /tmp/vufind_sessions/sess_8p92h6j2opeg154uekgst81h6l