Dual-Specificity Phosphatase CDC25B Was Inhibited by Natural Product HB-21 Through Covalently Binding to the Active Site

Cysteine 473, within the active site of the enzyme, Cdc25B, is catalytically essential for substrate activation. The most well-reported inhibitors of Cdc25 phosphatases, especially quinone-type inhibitors, function by inducing irreversible oxidation at this active site of cysteine. Here, we identifi...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Shoude, Jia, Qiangqiang, Gao, Qiang, Fan, Xueru, Weng, Yuxin, Su, Zhanhai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282036/
https://www.ncbi.nlm.nih.gov/pubmed/30555816
http://dx.doi.org/10.3389/fchem.2018.00531

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282036/
https://www.ncbi.nlm.nih.gov/pubmed/30555816
http://dx.doi.org/10.3389/fchem.2018.00531

Ejemplares similares