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Dual-Specificity Phosphatase CDC25B Was Inhibited by Natural Product HB-21 Through Covalently Binding to the Active Site
Cysteine 473, within the active site of the enzyme, Cdc25B, is catalytically essential for substrate activation. The most well-reported inhibitors of Cdc25 phosphatases, especially quinone-type inhibitors, function by inducing irreversible oxidation at this active site of cysteine. Here, we identifi...
Autores principales: | Zhang, Shoude, Jia, Qiangqiang, Gao, Qiang, Fan, Xueru, Weng, Yuxin, Su, Zhanhai |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282036/ https://www.ncbi.nlm.nih.gov/pubmed/30555816 http://dx.doi.org/10.3389/fchem.2018.00531 |
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