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Cardiac and skeletal actin substrates uniquely tune cardiac myosin strain-dependent mechanics

Cardiac ventricular myosin (βmys) translates actin by transducing ATP free energy into mechanical work during muscle contraction. Unitary βmys translation of actin is the step-size. In vitro and in vivo βmys regulates contractile force and velocity autonomously by remixing three different step-sizes...

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Detalles Bibliográficos
Autores principales: Wang, Yihua, Ajtai, Katalin, Burghardt, Thomas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282072/
https://www.ncbi.nlm.nih.gov/pubmed/30463911
http://dx.doi.org/10.1098/rsob.180143