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Lipoxin A4 receptor agonist BML-111 induces autophagy in alveolar macrophages and protects from acute lung injury by activating MAPK signaling

BACKGROUND: Acute lung injury (ALI) is a life-threatening lung disease where alveolar macrophages (AMs) play a central role both in the early phase to initiate inflammatory responses and in the late phase to promote tissue repair. In this study, we examined whether BML-111, a lipoxin A4 receptor ago...

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Detalles Bibliográficos
Autores principales: Liu, Huaizheng, Zhou, Kefu, Liao, Liangkan, Zhang, Tianyi, Yang, Mingshi, Sun, Chuanzheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282312/
https://www.ncbi.nlm.nih.gov/pubmed/30518355
http://dx.doi.org/10.1186/s12931-018-0937-2