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High-yield production of human Dicer by transfection of human HEK293-EBNA1 cells grown in suspension
BACKGROUND: Dicer is a 219-kDa protein that plays key roles in gene regulation, particularly as the ribonuclease III enzyme responsible for cleaving precursor miRNA substrates. Its enzymatic activity is highly regulated by protein factors, and this regulation can impact on the levels of miRNAs and m...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282390/ https://www.ncbi.nlm.nih.gov/pubmed/30522464 http://dx.doi.org/10.1186/s12896-018-0485-3 |