Design, synthesis and biological evaluation of novel 4-anlinoquinazoline derivatives as EGFR inhibitors with the potential to inhibit the gefitinib-resistant nonsmall cell lung cancers

A series of quinazoline derivatives with benzylidene hydrazine carboxamide were designed and synthesised as EGFR inhibitors. Most compounds exhibited exceptional anti-proliferative activity against A549, HepG2, MCF-7 and H1975 cells. Furthermore, six compounds demonstrated excellent inhibition activ...

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Detalles Bibliográficos
Autores principales: Wang, Caolin, Xu, Shan, Peng, Liang, Zhang, Bingliang, Zhang, Hong, Hu, Yingying, Zheng, Pengwu, Zhu, Wufu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282443/
https://www.ncbi.nlm.nih.gov/pubmed/30835140
http://dx.doi.org/10.1080/14756366.2018.1518957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282443/
https://www.ncbi.nlm.nih.gov/pubmed/30835140
http://dx.doi.org/10.1080/14756366.2018.1518957

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