Design and Synthesis of Bioisosteres of Acylhydrazones as Stable Inhibitors of the Aspartic Protease Endothiapepsin

Acylhydrazone‐based dynamic combinatorial chemistry (DCC) is a powerful strategy for the rapid identification of novel hits. Even though acylhydrazones are important structural motifs in medicinal chemistry, their further progression in development may be hampered by major instability and potential...

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Detalles Bibliográficos
Autores principales: Jumde, Varsha R., Mondal, Milon, Gierse, Robin M., Unver, M. Yagiz, Magari, Francesca, van Lier, Roos C. W., Heine, Andreas, Klebe, Gerhard, Hirsch, Anna K. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282583/
https://www.ncbi.nlm.nih.gov/pubmed/30178575
http://dx.doi.org/10.1002/cmdc.201800446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282583/
https://www.ncbi.nlm.nih.gov/pubmed/30178575
http://dx.doi.org/10.1002/cmdc.201800446

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