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Antibody adsorption in protein‐A affinity chromatography – in situ measurement of nanoscale structure by small‐angle X‐ray scattering

Protein‐A chromatography is the most widely used chromatography step in downstream processing of antibodies. A deeper understanding of the influence of the surface topology on a molecular/nanoscale level on adsorption is essential for further improvement. It is not clear if the binding is homogenous...

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Detalles Bibliográficos
Autores principales:	Plewka, Jacek, Silva, Gonçalo L., Tscheließnig, Rupert, Rennhofer, Harald, Dias‐Cabral, Cristina, Jungbauer, Alois, Lichtenegger, Helga C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Liquid Chromatography
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282589/ https://www.ncbi.nlm.nih.gov/pubmed/30240534 http://dx.doi.org/10.1002/jssc.201800776

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