Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis

BACKGROUND & AIMS: Transdifferentiation of hepatic stellate cells (HSCs) into myofibroblasts is a key event in the pathogenesis of liver fibrosis. Transforming growth factor β (TGF-β) and platelet-derived growth factor (PDGF) are canonical HSC activators after liver injury. The aim of this study...

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Detalles Bibliográficos
Autores principales: Martin-Mateos, Rosa, De Assuncao, Thiago M., Arab, Juan Pablo, Jalan-Sakrikar, Nidhi, Yaqoob, Usman, Greuter, Thomas, Verma, Vikas K., Mathison, Angela J., Cao, Sheng, Lomberk, Gwen, Mathurin, Philippe, Urrutia, Raul, Huebert, Robert C., Shah, Vijay H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282644/
https://www.ncbi.nlm.nih.gov/pubmed/30539787
http://dx.doi.org/10.1016/j.jcmgh.2018.09.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282644/
https://www.ncbi.nlm.nih.gov/pubmed/30539787
http://dx.doi.org/10.1016/j.jcmgh.2018.09.005

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