Cytochrome P450 3A Induction Predicts P‐glycoprotein Induction; Part 1: Establishing Induction Relationships Using Ascending Dose Rifampin

Drug transporter and cytochrome P450 expression is regulated by shared nuclear receptors and, hence, an inducer should induce both, although the magnitude may differ. The objective of this study was to establish relative induction relationships between CYP3A and drug transporters (P‐glycoprotein (P‐...

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Detalles Bibliográficos
Autores principales: Lutz, Justin D., Kirby, Brian J., Wang, Lu, Song, Qinghua, Ling, John, Massetto, Benedetta, Worth, Angela, Kearney, Brian P., Mathias, Anita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282691/
https://www.ncbi.nlm.nih.gov/pubmed/29569723
http://dx.doi.org/10.1002/cpt.1073

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282691/
https://www.ncbi.nlm.nih.gov/pubmed/29569723
http://dx.doi.org/10.1002/cpt.1073

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