Enhanced activity of an ADAMTS‐13 variant (R568K/F592Y/R660K/Y661F/Y665F) against platelet agglutination in vitro and in a murine model of acute ischemic stroke

ESSENTIALS: ADAMTS13 requires a substrate‐induced conformational change to attain full activity in vitro. The efficacy of wild type ADAMTS13 in models of thrombosis/stroke may be enhanced by pre‐activation. A pre‐activated ADAMTS13 variant exhibits enhanced proteolysis of platelet agglutinates. This...

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Detalles Bibliográficos
Autores principales: South, K., Denorme, F., Salles‐Crawley, I. I., De Meyer, S. F., Lane, D. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
PLATELETS
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282751/
https://www.ncbi.nlm.nih.gov/pubmed/30152919
http://dx.doi.org/10.1111/jth.14275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282751/
https://www.ncbi.nlm.nih.gov/pubmed/30152919
http://dx.doi.org/10.1111/jth.14275

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