Evaluation of Potential Disease‐Mediated Drug–Drug Interaction in Patients With Moderate‐to‐Severe Atopic Dermatitis Receiving Dupilumab

This open‐label drug–drug interaction study assessed whether blockade by dupilumab of interleukin (IL)‐4 and IL‐13 signaling affects the pharmacokinetics of drugs metabolized by cytochrome P450 (CYP450) enzymes. The pharmacokinetics of five CYP450 substrates given orally (midazolam, omeprazole, S‐wa...

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Detalles Bibliográficos
Autores principales: Davis, John D., Bansal, Ashish, Hassman, David, Akinlade, Bolanle, Li, Meng, Li, Zhaoyang, Swanson, Brian, Hamilton, Jennifer D., DiCioccio, A. Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282936/
https://www.ncbi.nlm.nih.gov/pubmed/29498038
http://dx.doi.org/10.1002/cpt.1058

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282936/
https://www.ncbi.nlm.nih.gov/pubmed/29498038
http://dx.doi.org/10.1002/cpt.1058

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