Immune Response-Dependent Assembly of IMP Dehydrogenase Filaments

Inosine monophosphate dehydrogenase (IMPDH) catalyzes the conversion of IMP to xanthosine monophosphate, the rate-limiting step in de novo guanosine monophosphate (GMP) synthesis. In cultured cells, IMPDH polymerizes into micron-scale filamentous structures when GMP synthesis is inhibited by depleti...

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Detalles Bibliográficos
Autores principales: Calise, S. John, Abboud, Georges, Kasahara, Hideko, Morel, Laurence, Chan, Edward K. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283036/
https://www.ncbi.nlm.nih.gov/pubmed/30555474
http://dx.doi.org/10.3389/fimmu.2018.02789

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283036/
https://www.ncbi.nlm.nih.gov/pubmed/30555474
http://dx.doi.org/10.3389/fimmu.2018.02789

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