Cargando…

ZYH005, a novel DNA intercalator, overcomes all-trans retinoic acid resistance in acute promyelocytic leukemia

Despite All-trans retinoic acid (ATRA) has transformed acute promyelocytic leukemia (APL) from the most fatal to the most curable hematological cancer, there remains a clinical challenge that many high-risk APL patients who fail to achieve a complete molecular remission or relapse and become resista...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tong, Qingyi, You, Huijuan, Chen, Xintao, Wang, Kongchao, Sun, Weiguang, Pei, Yufeng, Zhao, Xiaodan, Yuan, Ming, Zhu, Hucheng, Luo, Zengwei, Zhang, Yonghui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283422/ https://www.ncbi.nlm.nih.gov/pubmed/29554366 http://dx.doi.org/10.1093/nar/gky202

Ejemplares similares

Stereochemical control of nucleosome targeting by platinum-intercalator antitumor agents
por: Chua, Eugene Y.D., et al.
Publicado: (2015)

Critical role of DNA intercalation in enzyme-catalyzed nucleotide flipping
por: Hendershot, Jenna M., et al.
Publicado: (2014)

AP-endonuclease 1 sculpts DNA through an anchoring tyrosine residue on the DNA intercalating loop
por: Hoitsma, Nicole M, et al.
Publicado: (2020)

Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs
por: Schlegel, Mark K, et al.
Publicado: (2021)

Inhibition of BACH1 (FANCJ) helicase by backbone discontinuity is overcome by increased motor ATPase or length of loading strand
por: Gupta, Rigu, et al.
Publicado: (2006)

Conformations of Flanking Bases in HIV-1 RNA DIS Kissing Complexes Studied by Molecular Dynamics
por: Réblová, Kamila, et al.
Publicado: (2007)

Components of variance in transcriptomics based on electrophoretic separation of cDNA fragments (cDNA-AFLP)
por: Weiberg, Arne, et al.
Publicado: (2009)

RNA pseudoknots
por: Westhof, Eric, et al.
Publicado: (1992)

Isometric artifacts from polymerase chain reaction‐massively parallel sequencing analysis of short tandem repeat loci: An emerging issue from a new technology?
por: Zupanič Pajnič, Irena, et al.
Publicado: (2022)

AtTrm5a catalyses 1-methylguanosine and 1-methylinosine formation on tRNAs and is important for vegetative and reproductive growth in Arabidopsis thaliana
por: Jin, Xiaohuan, et al.
Publicado: (2019)

Chemical and structural characterization of interstrand cross-links formed between abasic sites and adenine residues in duplex DNA
por: Price, Nathan E., et al.
Publicado: (2015)

Identification of metabolically stable 5′-phosphate analogs that support single-stranded siRNA activity
por: Prakash, Thazha P., et al.
Publicado: (2015)

Outwitting EF-Tu and the ribosome: translation with d-amino acids
por: Achenbach, John, et al.
Publicado: (2015)

Synthesis and triplex-forming properties of oligonucleotides capable of recognizing corresponding DNA duplexes containing four base pairs
por: Ohkubo, Akihiro, et al.
Publicado: (2015)

Site-specific labeling of RNA by combining genetic alphabet expansion transcription and copper-free click chemistry
por: Someya, Tatsuhiko, et al.
Publicado: (2015)

Chemical intervention of the NM23-H2 transcriptional programme on c-MYC via a novel small molecule
por: Shan, Chan, et al.
Publicado: (2015)

Linking two DNA duplexes with a rigid linker for DNA nanotechnology
por: Tashiro, Ryu, et al.
Publicado: (2015)

Xylonucleic acid: synthesis, structure, and orthogonal pairing properties
por: Maiti, Mohitosh, et al.
Publicado: (2015)

The unusual and dynamic character of PX-DNA
por: Niu, Dong, et al.
Publicado: (2015)

Accurate placement of substrate RNA by Gar1 in H/ACA RNA-guided pseudouridylation
por: Wang, Peng, et al.
Publicado: (2015)

DNA–DNA kissing complexes as a new tool for the assembly of DNA nanostructures
por: Barth, Anna, et al.
Publicado: (2016)

Periodic-shRNA molecules are capable of gene silencing, cytotoxicity and innate immune activation in cancer cells
por: Shopsowitz, Kevin E., et al.
Publicado: (2016)

The use of modified and non-natural nucleotides provide unique insights into pro-mutagenic replication catalyzed by polymerase eta
por: Choi, Jung-Suk, et al.
Publicado: (2016)

Exploded view of higher order G-quadruplex structures through click-chemistry assisted single-molecule mechanical unfolding
por: Selvam, Sangeetha, et al.
Publicado: (2016)

Direct evidence of mitochondrial G-quadruplex DNA by using fluorescent anti-cancer agents
por: Huang, Wei-Chun, et al.
Publicado: (2015)

Thermodynamic properties of water molecules in the presence of cosolute depend on DNA structure: a study using grid inhomogeneous solvation theory
por: Nakano, Miki, et al.
Publicado: (2015)

Thermodynamic insights into 2-thiouridine-enhanced RNA hybridization
por: Larsen, Aaron T., et al.
Publicado: (2015)

Agonistic aptamer to the insulin receptor leads to biased signaling and functional selectivity through allosteric modulation
por: Yunn, Na-Oh, et al.
Publicado: (2015)

Site specific replacements of a single loop nucleoside with a dibenzyl linker may switch the activity of TBA from anticoagulant to antiproliferative
por: Scuotto, Maria, et al.
Publicado: (2015)

Crosslinking reactions of 4-amino-6-oxo-2-vinylpyrimidine with guanine derivatives and structural analysis of the adducts
por: Kusano, Shuhei, et al.
Publicado: (2015)

Site-specific replacement of the thymine methyl group by fluorine in thrombin binding aptamer significantly improves structural stability and anticoagulant activity
por: Virgilio, Antonella, et al.
Publicado: (2015)

Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages
por: Wan, W. Brad, et al.
Publicado: (2014)

Locating the uracil-5-yl radical formed upon photoirradiation of 5-bromouracil-substituted DNA
por: Hashiya, Fumitaka, et al.
Publicado: (2014)

The phosphate clamp: sequence selective nucleic acid binding profiles and conformational induction of endonuclease inhibition by cationic Triplatin complexes
por: Prisecaru, Andreea, et al.
Publicado: (2014)

High-throughput screening identifies small molecules that enhance the pharmacological effects of oligonucleotides
por: Yang, B., et al.
Publicado: (2015)

iSpinach: a fluorogenic RNA aptamer optimized for in vitro applications
por: Autour, Alexis, et al.
Publicado: (2016)

G-register exchange dynamics in guanine quadruplexes
por: Harkness, Robert W., et al.
Publicado: (2016)

Direct and site-specific quantification of RNA 2′-O-methylation by PCR with an engineered DNA polymerase
por: Aschenbrenner, Joos, et al.
Publicado: (2016)

Deciphering the genomic targets of alkylating polyamide conjugates using high-throughput sequencing
por: Chandran, Anandhakumar, et al.
Publicado: (2016)

Pharmacologic efficacy of PU.1 inhibition by heterocyclic dications: a mechanistic analysis
por: Stephens, Dominique C., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_qssso7f5a2j9j4pbdj7mf20p93