ViFi: accurate detection of viral integration and mRNA fusion reveals indiscriminate and unregulated transcription in proximal genomic regions in cervical cancer

The integration of viral sequences into the host genome is an important driver of tumorigenesis in many viral mediated cancers, notably cervical cancer and hepatocellular carcinoma. We present ViFi, a computational method that combines phylogenetic methods with reference-based read mapping to detect...

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Detalles Bibliográficos
Autores principales: Nguyen, Nam-phuong D, Deshpande, Viraj, Luebeck, Jens, Mischel, Paul S, Bafna, Vineet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283451/
https://www.ncbi.nlm.nih.gov/pubmed/29579309
http://dx.doi.org/10.1093/nar/gky180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283451/
https://www.ncbi.nlm.nih.gov/pubmed/29579309
http://dx.doi.org/10.1093/nar/gky180

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