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ViFi: accurate detection of viral integration and mRNA fusion reveals indiscriminate and unregulated transcription in proximal genomic regions in cervical cancer
The integration of viral sequences into the host genome is an important driver of tumorigenesis in many viral mediated cancers, notably cervical cancer and hepatocellular carcinoma. We present ViFi, a computational method that combines phylogenetic methods with reference-based read mapping to detect...
Autores principales: | Nguyen, Nam-phuong D, Deshpande, Viraj, Luebeck, Jens, Mischel, Paul S, Bafna, Vineet |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283451/ https://www.ncbi.nlm.nih.gov/pubmed/29579309 http://dx.doi.org/10.1093/nar/gky180 |
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