The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity

DExD/H box RNA helicases, such as the RIG-I-like receptors (RLR), are important components of the innate immune system. Here we demonstrate a pivotal and sex-specific role for the heterosomal isoforms of the DEAD box RNA helicase DDX3 in the immune system. Mice lacking DDX3X during hematopoiesis sho...

Descripción completa

Detalles Bibliográficos
Autores principales: Szappanos, Daniel, Tschismarov, Roland, Perlot, Thomas, Westermayer, Sandra, Fischer, Katrin, Platanitis, Ekaterini, Kallinger, Fabian, Novatchkova, Maria, Lassnig, Caroline, Müller, Mathias, Sexl, Veronika, Bennett, Keiryn L., Foong-Sobis, Michelle, Penninger, Josef M., Decker, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283616/
https://www.ncbi.nlm.nih.gov/pubmed/30475900
http://dx.doi.org/10.1371/journal.ppat.1007397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283616/
https://www.ncbi.nlm.nih.gov/pubmed/30475900
http://dx.doi.org/10.1371/journal.ppat.1007397

Ejemplares similares