Identification and binding mode of a novel Leishmania Trypanothione reductase inhibitor from high throughput screening

Trypanothione reductase (TR) is considered to be one of the best targets to find new drugs against Leishmaniasis. This enzyme is fundamental for parasite survival in the host since it reduces trypanothione, a molecule used by the tryparedoxin/tryparedoxin peroxidase system of Leishmania to neutraliz...

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Detalles Bibliográficos
Autores principales: Turcano, Lorenzo, Torrente, Esther, Missineo, Antonino, Andreini, Matteo, Gramiccia, Marina, Di Muccio, Trentina, Genovese, Ilaria, Fiorillo, Annarita, Harper, Steven, Bresciani, Alberto, Colotti, Gianni, Ilari, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283646/
https://www.ncbi.nlm.nih.gov/pubmed/30475811
http://dx.doi.org/10.1371/journal.pntd.0006969

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283646/
https://www.ncbi.nlm.nih.gov/pubmed/30475811
http://dx.doi.org/10.1371/journal.pntd.0006969

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