In vivo cell type-specific CRISPR knockdown of dopamine beta hydroxylase reduces locus coeruleus evoked wakefulness

Locus coeruleus (LC) neurons in the brainstem have long been associated with attention and arousal. Optogenetic stimulation of LC-NE neurons induces immediate sleep-to-wake transitions. However, LC neurons also secrete other neurotransmitters in addition to NE. To interrogate the role of NE derived...

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Detalles Bibliográficos
Autores principales: Yamaguchi, Hiroshi, Hopf, F. Woodward, Li, Shi-Bin, de Lecea, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283864/
https://www.ncbi.nlm.nih.gov/pubmed/30523254
http://dx.doi.org/10.1038/s41467-018-07566-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283864/
https://www.ncbi.nlm.nih.gov/pubmed/30523254
http://dx.doi.org/10.1038/s41467-018-07566-3

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