Long-Term In Vitro Expansion of Epithelial Stem Cells Enabled by Pharmacological Inhibition of PAK1-ROCK-Myosin II and TGF-β Signaling

Despite substantial self-renewal capability in vivo, epithelial stem and progenitor cells located in various tissues expand for a few passages in vitro in feeder-free condition before they succumb to growth arrest. Here, we describe the EpiX method, which utilizes small molecules that inhibit PAK1-R...

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Detalles Bibliográficos
Autores principales: Zhang, Chengkang, Lee, Hyung Joo, Shrivastava, Anura, Wang, Ruipeng, McQuiston, Travis J., Challberg, Sharon S., Pollok, Brian A., Wang, Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284236/
https://www.ncbi.nlm.nih.gov/pubmed/30332641
http://dx.doi.org/10.1016/j.celrep.2018.09.072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284236/
https://www.ncbi.nlm.nih.gov/pubmed/30332641
http://dx.doi.org/10.1016/j.celrep.2018.09.072

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