Rho GTPase Activating Protein 24 (ARHGAP24) Regulates the Anti-Cancer Activity of Sorafenib Against Breast Cancer MDA-MB-231 Cells via the Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathway

BACKGROUND: STAT3 has emerged as a novel potential target for sorafenib, a multikinase inhibitor, in the context of cancer therapy. ARHGAP24 is a Rac-specific Rho GTPase-activating protein (Rho GAP), which can convert Rho GTPases to an inactive state. It has been proved to be an oncosuppressor prote...

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Detalles Bibliográficos
Autores principales: Dai, Xianping, Geng, Feng, Dai, Jiale, Li, Mengshun, Liu, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2018
Materias:
Lab/In Vitro Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284358/
https://www.ncbi.nlm.nih.gov/pubmed/30499465
http://dx.doi.org/10.12659/MSM.911394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284358/
https://www.ncbi.nlm.nih.gov/pubmed/30499465
http://dx.doi.org/10.12659/MSM.911394

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