Development of Severe Combined Immunodeficient (SCID) Pig Models for Translational Cancer Modeling: Future Insights on How Humanized SCID Pigs Can Improve Preclinical Cancer Research

Within the last decade there have been several severe combined immunodeficient (SCID) pig models discovered or genetically engineered. The animals have mutations in ARTEMIS, IL2RG, or RAG1/2 genes, or combinations thereof, providing SCID pigs with NK cells, but deficient in T and B cells, or deficie...

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Detalles Bibliográficos
Autores principales: Boettcher, Adeline N., Loving, Crystal L., Cunnick, Joan E., Tuggle, Christopher K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284365/
https://www.ncbi.nlm.nih.gov/pubmed/30560086
http://dx.doi.org/10.3389/fonc.2018.00559

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284365/
https://www.ncbi.nlm.nih.gov/pubmed/30560086
http://dx.doi.org/10.3389/fonc.2018.00559

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