Charge variant native mass spectrometry benefits mass precision and dynamic range of monoclonal antibody intact mass analysis

The preponderance and diversity of charge variants in therapeutic monoclonal antibodies has implications for antibody efficacy and degradation. Understanding the extent and impact of minor antibody variants is of great interest, and it is also a critical regulatory requirement. Traditionally, a comb...

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Detalles Bibliográficos
Autores principales: Bailey, Aaron O., Han, Guanghui, Phung, Wilson, Gazis, Paul, Sutton, Jennifer, Josephs, Jonathan L., Sandoval, Wendy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284562/
https://www.ncbi.nlm.nih.gov/pubmed/30339478
http://dx.doi.org/10.1080/19420862.2018.1521131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284562/
https://www.ncbi.nlm.nih.gov/pubmed/30339478
http://dx.doi.org/10.1080/19420862.2018.1521131

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