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Charge variant native mass spectrometry benefits mass precision and dynamic range of monoclonal antibody intact mass analysis
The preponderance and diversity of charge variants in therapeutic monoclonal antibodies has implications for antibody efficacy and degradation. Understanding the extent and impact of minor antibody variants is of great interest, and it is also a critical regulatory requirement. Traditionally, a comb...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284562/ https://www.ncbi.nlm.nih.gov/pubmed/30339478 http://dx.doi.org/10.1080/19420862.2018.1521131 |