MicroRNA therapeutics: design of single-stranded miR-216b mimics to target KRAS in pancreatic cancer cells

Datasets reporting microRNA expression profiles in normal and cancer cells show that miR-216b is aberrantly downregulated in pancreatic ductal adenocarcinoma (PDAC). We found that KRAS, whose mutant G12D allele drives the pathogenesis of PDAC, is a target of miR-216b. To suppress oncogenic KRAS in P...

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Detalles Bibliográficos
Autores principales: Ferino, Annalisa, Miglietta, Giulia, Picco, Raffaella, Vogel, Stefan, Wengel, Jesper, Xodo, Luigi E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284578/
https://www.ncbi.nlm.nih.gov/pubmed/30306823
http://dx.doi.org/10.1080/15476286.2018.1526536

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284578/
https://www.ncbi.nlm.nih.gov/pubmed/30306823
http://dx.doi.org/10.1080/15476286.2018.1526536

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