Cargando…

Mycobacterium tuberculosis induces decelerated bioenergetic metabolism in human macrophages

How Mycobacterium tuberculosis (Mtb) rewires macrophage energy metabolism to facilitate survival is poorly characterized. Here, we used extracellular flux analysis to simultaneously measure the rates of glycolysis and respiration in real time. Mtb infection induced a quiescent energy phenotype in hu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cumming, Bridgette M, Addicott, Kelvin W, Adamson, John H, Steyn, Adrie JC
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Biochemistry and Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286123/ https://www.ncbi.nlm.nih.gov/pubmed/30444490 http://dx.doi.org/10.7554/eLife.39169

Ejemplares similares

Host Bioenergetic Parameters Reveal Cytotoxicity of Antituberculosis Drugs Undetected Using Conventional Viability Assays
por: Cumming, Bridgette M., et al.
Publicado: (2021)

Hydrogen sulfide dysregulates the immune response by suppressing central carbon metabolism to promote tuberculosis
por: Rahman, Md. Aejazur, et al.
Publicado: (2020)

Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells
por: Hung, Yin P, et al.
Publicado: (2017)

Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia
por: Nelson, Margaret AM, et al.
Publicado: (2021)

Hydrogen sulfide blocks HIV rebound by maintaining mitochondrial bioenergetics and redox homeostasis
por: Pal, Virender Kumar, et al.
Publicado: (2021)

Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases
por: Mehta, Ved, et al.
Publicado: (2022)

A tRNA modification in Mycobacterium tuberculosis facilitates optimal intracellular growth
por: Tomasi, Francesca G, et al.
Publicado: (2023)

Turning the respiratory flexibility of Mycobacterium tuberculosis against itself
por: Lamprecht, Dirk A., et al.
Publicado: (2016)

Mycobacterium tuberculosis H(2)S Functions as a Sink to Modulate Central Metabolism, Bioenergetics, and Drug Susceptibility
por: Kunota, Tafara T. R., et al.
Publicado: (2021)

Compromised Metabolic Reprogramming Is an Early Indicator of CD8(+) T Cell Dysfunction during Chronic Mycobacterium tuberculosis Infection
por: Russell, Shannon L., et al.
Publicado: (2019)

Mycobacterium tuberculosis arrests host cycle at the G(1)/S transition to establish long term infection
por: Cumming, Bridgette M., et al.
Publicado: (2017)

Correction: Mycobacterium tuberculosis arrests host cycle at the G(1)/S transition to establish long term infection
por: Cumming, Bridgette M., et al.
Publicado: (2017)

Relevance of the Warburg Effect in Tuberculosis for Host-Directed Therapy
por: Cumming, Bridgette M., et al.
Publicado: (2020)

Release of cholesterol-rich particles from the macrophage plasma membrane during movement of filopodia and lamellipodia
por: Hu, Xuchen, et al.
Publicado: (2019)

Gene and protein expression and metabolic flux analysis reveals metabolic scaling in liver ex vivo and in vivo
por: Akingbesote, Ngozi D, et al.
Publicado: (2023)

Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer
por: Kang, Yun Pyo, et al.
Publicado: (2019)

Correction: Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer
por: Kang, Yun Pyo, et al.
Publicado: (2019)

Mitochondria-specific photoactivation to monitor local sphingosine metabolism and function
por: Feng, Suihan, et al.
Publicado: (2018)

Drosophila STING protein has a role in lipid metabolism
por: Akhmetova, Katarina, et al.
Publicado: (2021)

Effects of microcompartmentation on flux distribution and metabolic pools in Chlamydomonas reinhardtii chloroplasts
por: Küken, Anika, et al.
Publicado: (2018)

Evolution of a plant gene cluster in Solanaceae and emergence of metabolic diversity
por: Fan, Pengxiang, et al.
Publicado: (2020)

Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria
por: Nowinski, Sara M, et al.
Publicado: (2020)

Instability in NAD(+) metabolism leads to impaired cardiac mitochondrial function and communication
por: Lauritzen, Knut H, et al.
Publicado: (2021)

Hormone-sensitive lipase couples intergenerational sterol metabolism to reproductive success
por: Heier, Christoph, et al.
Publicado: (2021)

Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context
por: Kerk, Samuel A, et al.
Publicado: (2022)

A selective gut bacterial bile salt hydrolase alters host metabolism
por: Yao, Lina, et al.
Publicado: (2018)

A tryparedoxin-coupled biosensor reveals a mitochondrial trypanothione metabolism in trypanosomes
por: Ebersoll, Samantha, et al.
Publicado: (2020)

A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis
por: Gupta, Ritu, et al.
Publicado: (2019)

MYC overrides HIF-1α to regulate proliferating primary cell metabolism in hypoxia
por: Copeland, Courtney A, et al.
Publicado: (2023)

Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins
por: Paxman, Ryan, et al.
Publicado: (2018)

Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye
por: Kanow, Mark A, et al.
Publicado: (2017)

Tandem riboswitches form a natural Boolean logic gate to control purine metabolism in bacteria
por: Sherlock, Madeline E, et al.
Publicado: (2018)

Long-lived metabolic enzymes in the crystalline lens identified by pulse-labeling of mice and mass spectrometry
por: Liu, Pan, et al.
Publicado: (2019)

Extracellular electron transfer increases fermentation in lactic acid bacteria via a hybrid metabolism
por: Tejedor-Sanz, Sara, et al.
Publicado: (2022)

Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism
por: Ryan, Dylan Gerard, et al.
Publicado: (2021)

Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells
por: Emrich, Scott M, et al.
Publicado: (2023)

A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols
por: Maini Rekdal, Vayu, et al.
Publicado: (2020)

OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21
por: Pereira, Renata O, et al.
Publicado: (2021)

Association of egg consumption, metabolic markers, and risk of cardiovascular diseases: A nested case-control study
por: Pan, Lang, et al.
Publicado: (2022)

Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells
por: Vilaplana-Lopera, Nuria, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_e3ba5tvd16q22535uvvfhf03mi