Host-targeted niclosamide inhibits C. difficile virulence and prevents disease in mice without disrupting the gut microbiota

Clostridium difficile is the leading cause of nosocomial diarrhea and colitis in the industrialized world. Disruption of the protective gut microbiota by antibiotics enables colonization by multidrug-resistant C. difficile, which secrete up to three different protein toxins that are responsible for...

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Detalles Bibliográficos
Autores principales: Tam, John, Hamza, Therwa, Ma, Bing, Chen, Kevin, Beilhartz, Greg L., Ravel, Jacques, Feng, Hanping, Melnyk, Roman A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286312/
https://www.ncbi.nlm.nih.gov/pubmed/30531960
http://dx.doi.org/10.1038/s41467-018-07705-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286312/
https://www.ncbi.nlm.nih.gov/pubmed/30531960
http://dx.doi.org/10.1038/s41467-018-07705-w

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