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CASP4 gene silencing in epithelial cancer cells leads to impairment of cell migration, cell-matrix adhesion and tissue invasion

Inflammatory caspases, including human caspase-4 (CASP4), play key roles in innate immune responses to promote fusion of phagosomes harboring pathogenic bacteria with lysosomes, halt intracellular replication of pathogens, maturation and secretion of pro-inflammatory cytokines. The role of inflammat...

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Detalles Bibliográficos
Autores principales: Papoff, Giuliana, Presutti, Dario, Lalli, Cristiana, Bolasco, Giulia, Santini, Simonetta, Manelfi, Candida, Fustaino, Valentina, Alemà, Stefano, Ruberti, Giovina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286322/
https://www.ncbi.nlm.nih.gov/pubmed/30531914
http://dx.doi.org/10.1038/s41598-018-35792-8