Inhibitor binding mode and allosteric regulation of Na(+)-glucose symporters

Sodium-dependent glucose transporters (SGLTs) exploit sodium gradients to transport sugars across the plasma membrane. Due to their role in renal sugar reabsorption, SGLTs are targets for the treatment of type 2 diabetes. Current therapeutics are phlorizin derivatives that contain a sugar moiety bou...

Descripción completa

Detalles Bibliográficos
Autores principales: Bisignano, Paola, Ghezzi, Chiara, Jo, Hyunil, Polizzi, Nicholas F., Althoff, Thorsten, Kalyanaraman, Chakrapani, Friemann, Rosmarie, Jacobson, Matthew P., Wright, Ernest M., Grabe, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286348/
https://www.ncbi.nlm.nih.gov/pubmed/30532032
http://dx.doi.org/10.1038/s41467-018-07700-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286348/
https://www.ncbi.nlm.nih.gov/pubmed/30532032
http://dx.doi.org/10.1038/s41467-018-07700-1

Ejemplares similares