Lack of IFNγ signaling attenuates spread of influenza A virus in vivo and leads to reduced pathogenesis

IFNγ is a key regulator of inflammatory responses but its role in influenza A virus (IAV) pathogenesis is unclear. Our studies show that infection of mice lacking the IFNγ receptor (IFNγR(-/-)) at a dose which caused severe disease in wild type 129 Sv/Ev (WT) mice resulted in milder clinical symptom...

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Detalles Bibliográficos
Autores principales: Nicol, Marlynne Q., Campbell, Gillian M., Shaw, Darren J., Dransfield, Ian, Ligertwood, Yvonne, Beard, Philippa M., Nash, Anthony A., Dutia, Bernadette M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286381/
https://www.ncbi.nlm.nih.gov/pubmed/30390564
http://dx.doi.org/10.1016/j.virol.2018.10.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286381/
https://www.ncbi.nlm.nih.gov/pubmed/30390564
http://dx.doi.org/10.1016/j.virol.2018.10.017

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