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Lack of IFNγ signaling attenuates spread of influenza A virus in vivo and leads to reduced pathogenesis
IFNγ is a key regulator of inflammatory responses but its role in influenza A virus (IAV) pathogenesis is unclear. Our studies show that infection of mice lacking the IFNγ receptor (IFNγR(-/-)) at a dose which caused severe disease in wild type 129 Sv/Ev (WT) mice resulted in milder clinical symptom...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Academic Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286381/ https://www.ncbi.nlm.nih.gov/pubmed/30390564 http://dx.doi.org/10.1016/j.virol.2018.10.017 |