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SETDB1 Links the Meiotic DNA Damage Response to Sex Chromosome Silencing in Mice
Meiotic synapsis and recombination ensure correct homologous segregation and genetic diversity. Asynapsed homologs are transcriptionally inactivated by meiotic silencing, which serves a surveillance function and in males drives meiotic sex chromosome inactivation. Silencing depends on the DNA damage...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286383/ https://www.ncbi.nlm.nih.gov/pubmed/30393076 http://dx.doi.org/10.1016/j.devcel.2018.10.004 |