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PRedicting Outcomes For Crohn’s dIsease using a moLecular biomarkEr (PROFILE): protocol for a multicentre, randomised, biomarker-stratified trial

BACKGROUND: The course of Crohn’s disease (CD) varies substantially between individuals, but reliable prognostic markers do not exist. This hinders disease management because patients with aggressive disease are undertreated by conventional ‘step-up’ therapy (in which treatment is gradually escalate...

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Detalles Bibliográficos
Autores principales: Parkes, Miles, Noor, Nurulamin M, Dowling, Francis, Leung, Harvey, Bond, Simon, Whitehead, Lynne, Upponi, Sara, Kinnon, Paul, Sandham, Andrew P, Lyons, Paul A, McKinney, Eoin F, Smith, Kenneth G C, Lee, James C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286485/
https://www.ncbi.nlm.nih.gov/pubmed/30523133
http://dx.doi.org/10.1136/bmjopen-2018-026767