Mutation-Specific Signaling Profiles and Kinase Inhibitor Sensitivities of Juvenile Myelomonocytic Leukemia Revealed by Induced Pluripotent Stem Cells

Juvenile myelomonocytic leukemia (JMML) is an uncommon myeloproliferative neoplasm driven by Ras pathway mutations and hyperactive Ras/MAPK signaling. Outcomes for many children with JMML remain dismal with current standard-of-care cytoreductive chemotherapy and hematopoietic stem cell transplantati...

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Detalles Bibliográficos
Autores principales: Tasian, Sarah K, Casas, Jessica A, Posocco, David, Gandre-Babbe, Shilpa, Gagne, Alyssa L, Liang, Ge, Loh, Mignon L, Weiss, Mitchell J, French, Deborah L, Chou, Stella T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286697/
https://www.ncbi.nlm.nih.gov/pubmed/29884903
http://dx.doi.org/10.1038/s41375-018-0169-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286697/
https://www.ncbi.nlm.nih.gov/pubmed/29884903
http://dx.doi.org/10.1038/s41375-018-0169-y

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