Suppression of mTORC1 activity in senescent Ras-transformed cells neither restores autophagy nor abrogates apoptotic death caused by inhibition of MEK/ERK kinases

Autophagy is conservative catabolic process that degrades organelles, in particular, mitochondria, and misfolded proteins within the lysosomes, thus maintaining cellular viability. Despite the close relationship between mitochondrial dysfunction and cellular senescence, it is unclear how mitochondri...

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Detalles Bibliográficos
Autores principales: Kochetkova, Elena Y., Blinova, Galina I., Bystrova, Olga A., Martynova, Marina G., Pospelov, Valeriy A., Pospelova, Tatiana V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286832/
https://www.ncbi.nlm.nih.gov/pubmed/30482887
http://dx.doi.org/10.18632/aging.101686

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286832/
https://www.ncbi.nlm.nih.gov/pubmed/30482887
http://dx.doi.org/10.18632/aging.101686

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