Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts

Here, we employed a “senolytic” assay system as a screening tool, with the goal of identifying and repurposing FDA-approved antibiotics, for the targeting of the senescent cell population. Briefly, we used two established human fibroblast cell lines (MRC-5 and/or BJ) as model systems to induce senes...

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Detalles Bibliográficos
Autores principales: Ozsvari, Bela, Nuttall, John R., Sotgia, Federica, Lisanti, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286845/
https://www.ncbi.nlm.nih.gov/pubmed/30428454
http://dx.doi.org/10.18632/aging.101633

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286845/
https://www.ncbi.nlm.nih.gov/pubmed/30428454
http://dx.doi.org/10.18632/aging.101633

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