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Azithromycin and Roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts
Here, we employed a “senolytic” assay system as a screening tool, with the goal of identifying and repurposing FDA-approved antibiotics, for the targeting of the senescent cell population. Briefly, we used two established human fibroblast cell lines (MRC-5 and/or BJ) as model systems to induce senes...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286845/ https://www.ncbi.nlm.nih.gov/pubmed/30428454 http://dx.doi.org/10.18632/aging.101633 |