Cargando…

A Comparative Study on the Efficacy of NLRP3 Inflammasome Signaling Inhibitors in a Pre-clinical Model of Bowel Inflammation

Nucleotide-binding oligomerization domain leucine rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome is pivotal in maintaining intestinal homeostasis and sustaining enteric immune responses in the setting of inflammatory bowel diseases. Drugs acting as NLRP3 blockers could repres...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pellegrini, Carolina, Fornai, Matteo, Colucci, Rocchina, Benvenuti, Laura, D’Antongiovanni, Vanessa, Natale, Gianfranco, Fulceri, Federica, Giorgis, Marta, Marini, Elisabetta, Gastaldi, Simone, Bertinaria, Massimo, Blandizzi, Corrado, Antonioli, Luca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287041/ https://www.ncbi.nlm.nih.gov/pubmed/30559669 http://dx.doi.org/10.3389/fphar.2018.01405

Ejemplares similares

Intestinal epithelial barrier and neuromuscular compartment in health and disease
por: D’Antongiovanni, Vanessa, et al.
Publicado: (2020)

The Adenosine System at the Crossroads of Intestinal Inflammation and Neoplasia
por: D’Antongiovanni, Vanessa, et al.
Publicado: (2020)

Managing Obesity and Related Comorbidities: A Potential Pharmacological Target in the Adenosine System?
por: D’Antongiovanni, Vanessa, et al.
Publicado: (2021)

Enteric Glia at the Crossroads between Intestinal Immune System and Epithelial Barrier: Implications for Parkinson Disease
por: Benvenuti, Laura, et al.
Publicado: (2020)

Glial A(2B) Adenosine Receptors Modulate Abnormal Tachykininergic Responses and Prevent Enteric Inflammation Associated with High Fat Diet-Induced Obesity
por: D’Antongiovanni, Vanessa, et al.
Publicado: (2020)

Phytochemicals as Novel Therapeutic Strategies for NLRP3 Inflammasome-Related Neurological, Metabolic, and Inflammatory Diseases
por: Pellegrini, Carolina, et al.
Publicado: (2019)

Canonical and Non-Canonical Activation of NLRP3 Inflammasome at the Crossroad between Immune Tolerance and Intestinal Inflammation
por: Pellegrini, Carolina, et al.
Publicado: (2017)

Pathophysiology of NSAID-Associated Intestinal Lesions in the Rat: Luminal Bacteria and Mucosal Inflammation as Targets for Prevention
por: Colucci, Rocchina, et al.
Publicado: (2018)

Preclinical Development of FA5, a Novel AMP-Activated Protein Kinase (AMPK) Activator as an Innovative Drug for the Management of Bowel Inflammation
por: Antonioli, Luca, et al.
Publicado: (2021)

Enteric α-synuclein impairs intestinal epithelial barrier through caspase-1-inflammasome signaling in Parkinson’s disease before brain pathology
por: Pellegrini, C., et al.
Publicado: (2022)

Author Correction: Enteric α-synuclein impairs intestinal epithelial barrier through caspase-1-inflammasome signaling in Parkinson’s disease before brain pathology
por: Pellegrini, C., et al.
Publicado: (2023)

Donepezil improves vascular function in a mouse model of Alzheimer’s disease
por: Pellegrini, Carolina, et al.
Publicado: (2021)

Involvement of the P2X7 Purinergic Receptor in Colonic Motor Dysfunction Associated with Bowel Inflammation in Rats
por: Antonioli, Luca, et al.
Publicado: (2014)

Dietary Supplement, Containing the Dry Extract of Curcumin, Emblica and Cassia, Counteracts Intestinal Inflammation and Enteric Dysmotility Associated with Obesity
por: D’Antongiovanni, Vanessa, et al.
Publicado: (2023)

Palmitoylethanolamide Counteracts Enteric Inflammation and Bowel Motor Dysfunctions in a Mouse Model of Alzheimer’s Disease
por: D’Antongiovanni, Vanessa, et al.
Publicado: (2021)

From the intestinal mucosal barrier to the enteric neuromuscular compartment: An integrated overview on the morphological changes in Parkinson’s disease
por: Pellegrini, Carolina, et al.
Publicado: (2021)

Prodromal Intestinal Events in Alzheimer’s Disease (AD): Colonic Dysmotility and Inflammation Are Associated with Enteric AD-Related Protein Deposition
por: Pellegrini, Carolina, et al.
Publicado: (2020)

Inflammatory Bowel Diseases: It's Time for the Adenosine System
por: Antonioli, Luca, et al.
Publicado: (2020)

NKG2A and COVID-19: another brick in the wall
por: Antonioli, Luca, et al.
Publicado: (2020)

The administration of Enterococcus faecium SF68 counteracts compositional shifts in the gut microbiota of diet-induced obese mice
por: Panattoni, Adelaide, et al.
Publicado: (2022)

An integrated assessment of histopathological changes of the enteric neuromuscular compartment in experimental colitis
por: Ippolito, Chiara, et al.
Publicado: (2015)

Anti-inflammatory Effects of Novel P2X4 Receptor Antagonists, NC-2600 and NP-1815-PX, in a Murine Model of Colitis
por: D’Antongiovanni, Vanessa, et al.
Publicado: (2022)

Luteolin Prevents Cardiometabolic Alterations and Vascular Dysfunction in Mice With HFD-Induced Obesity
por: Gentile, Daniela, et al.
Publicado: (2018)

Influence of the Serotonin Transporter 5HTTLPR Polymorphism on Symptom Severity in Irritable Bowel Syndrome
por: Colucci, Rocchina, et al.
Publicado: (2013)

Editorial: IBD Management—Novel Targets and Therapeutic Perspectives
por: Antonioli, Luca, et al.
Publicado: (2020)

Alteration of colonic excitatory tachykininergic motility and enteric inflammation following dopaminergic nigrostriatal neurodegeneration
por: Pellegrini, Carolina, et al.
Publicado: (2016)

Editorial: Neurological, Metabolic and Inflammatory Disorders: A Common Root in Inflammasome
por: Pellegrini, Carolina, et al.
Publicado: (2021)

Constipation, deficit in colon contractions and alpha-synuclein inclusions within the colon precede motor abnormalities and neurodegeneration in the central nervous system in a mouse model of alpha-synucleinopathy
por: Rota, Lucia, et al.
Publicado: (2019)

The flavonoid compound apigenin prevents colonic inflammation and motor dysfunctions associated with high fat diet-induced obesity
por: Gentile, Daniela, et al.
Publicado: (2018)

Chemical Modulation of the 1-(Piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazole-2-one Scaffold as a Novel NLRP3 Inhibitor
por: Gastaldi, Simone, et al.
Publicado: (2021)

Inflammasome Inhibitors
por: Bertinaria, Massimo
Publicado: (2021)

NLRP3 Inflammasome and Inflammatory Bowel Disease
por: Zhen, Yu, et al.
Publicado: (2019)

High Levels of β-Amyloid, Tau, and Phospho-Tau in Red Blood Cells as Biomarkers of Neuropathology in Senescence-Accelerated Mouse
por: Piccarducci, Rebecca, et al.
Publicado: (2019)

Purinergic Ligands as Potential Therapeutic Tools for the Treatment of Inflammation-Related Intestinal Diseases
por: Dal Ben, Diego, et al.
Publicado: (2018)

Role of NLRP3 inflammasome in inflammatory bowel diseases
por: Tourkochristou, Evanthia, et al.
Publicado: (2019)

Altered Expression Pattern of Molecular Factors Involved in Colonic Smooth Muscle Functions: An Immunohistochemical Study in Patients with Diverticular Disease
por: Mattii, Letizia, et al.
Publicado: (2013)

The Anti-Inflammatory and Pain-Relieving Effects of AR170, an Adenosine A(3) Receptor Agonist, in a Rat Model of Colitis
por: Antonioli, Luca, et al.
Publicado: (2020)

A Nutraceutical Strategy to Slowing Down the Progression of Cone Death in an Animal Model of Retinitis Pigmentosa
por: Piano, Ilaria, et al.
Publicado: (2019)

Immunohistochemical analysis of myenteric ganglia and interstitial cells of Cajal in ulcerative colitis
por: Bernardini, Nunzia, et al.
Publicado: (2012)

Ticagrelor Conditioning Effects Are Not Additive to Cardioprotection Induced by Direct NLRP3 Inflammasome Inhibition: Role of RISK, NLRP3, and Redox Cascades
por: Penna, Claudia, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ue1j7o2l12r6abl7ii40svgbb8