Bilirubin-Induced Oxidative Stress Leads to DNA Damage in the Cerebellum of Hyperbilirubinemic Neonatal Mice and Activates DNA Double-Strand Break Repair Pathways in Human Cells

Unconjugated bilirubin is considered a potent antioxidant when present at moderate levels. However, at high concentrations, it produces severe neurological damage and death associated with kernicterus due to oxidative stress and other mechanisms. While it is widely recognized that oxidative stress b...

Descripción completa

Detalles Bibliográficos
Autores principales: Rawat, Vipin, Bortolussi, Giulia, Gazzin, Silvia, Tiribelli, Claudio, Muro, Andrés F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287157/
https://www.ncbi.nlm.nih.gov/pubmed/30598724
http://dx.doi.org/10.1155/2018/1801243

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287157/
https://www.ncbi.nlm.nih.gov/pubmed/30598724
http://dx.doi.org/10.1155/2018/1801243

Ejemplares similares