Hyperactivation of Oncogenic JAK3 Mutants Depend on ATP Binding to the Pseudokinase Domain

Janus kinase 3 (JAK3) tyrosine kinase has a central role in the control of lymphopoiesis, and mutations in JAK3 can lead to either severe combined immunodeficiency or leukemia and lymphomas. JAK3 associates with the common gamma chain (γc) receptor and functions in a heteromeric signaling pair with...

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Detalles Bibliográficos
Autores principales: Raivola, Juuli, Hammarén, Henrik M., Virtanen, Anniina T., Bulleeraz, Vilasha, Ward, Alister C., Silvennoinen, Olli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287396/
https://www.ncbi.nlm.nih.gov/pubmed/30560087
http://dx.doi.org/10.3389/fonc.2018.00560

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287396/
https://www.ncbi.nlm.nih.gov/pubmed/30560087
http://dx.doi.org/10.3389/fonc.2018.00560

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