Cargando…
Structure-activity profiling of alkaloid natural product pharmacophores against a Schistosoma serotonin receptor
Serotonin (5-HT) is an important regulator of numerous aspects of flatworm biology, ranging from neuromuscular function to sexual maturation and egg laying. In the parasitic blood fluke Schistosoma mansoni, 5-HT targets several G-protein coupled receptors (GPCRs), one of which has been demonstrated...
Autores principales: | Marchant, Jonathan S., Harding, Wayne W., Chan, John D. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287472/ https://www.ncbi.nlm.nih.gov/pubmed/30297303 http://dx.doi.org/10.1016/j.ijpddr.2018.09.001 |
Ejemplares similares
-
Combining bioinformatics, cheminformatics, functional genomics and whole organism approaches for identifying epigenetic drug targets in Schistosoma mansoni
por: Padalino, Gilda, et al.
Publicado: (2018) -
TPT sulfonate, a single, oral dose schistosomicidal prodrug: In vivo efficacy, disposition and metabolic profiling
por: Wolfe, Alan R., et al.
Publicado: (2018) -
A mutational and molecular dynamics study of the cys-loop GABA receptor Hco-UNC-49 from Haemonchus contortus: Agonist recognition in the nematode GABA receptor family
por: Foster, Josh, et al.
Publicado: (2018) -
Clinical validation of molecular markers of macrocyclic lactone resistance in Dirofilaria immitis
por: Ballesteros, Cristina, et al.
Publicado: (2018) -
Anthelmintics – From Discovery to Resistance III (Indian Rocks Beach, FL, 2018)
por: Wolstenholme, Adrian J., et al.
Publicado: (2018)