Automethylation-induced conformational switch in Clr4/Suv39h maintains epigenetic stability

Histone H3 lysine 9 methylation (H3K9me) mediates heterochromatic gene silencing and is important for genome stability and regulation of gene expression(1–4). The establishment and epigenetic maintenance of heterochromatin involve the recruitment of H3K9 methyltransferases to specific sites on DNA f...

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Detalles Bibliográficos
Autores principales: Iglesias, Nahid, Currie, Mark A., Jih, Gloria, Paulo, Joao A., Siuti, Nertila, Kalocsay, Marian, Gygi, Steven P., Moazed, Danesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287498/
https://www.ncbi.nlm.nih.gov/pubmed/30051891
http://dx.doi.org/10.1038/s41586-018-0398-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287498/
https://www.ncbi.nlm.nih.gov/pubmed/30051891
http://dx.doi.org/10.1038/s41586-018-0398-2

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