Genome-wide Estrogen Receptor-α activation is sustained, not cyclical

Estrogen Receptor-alpha (ER) drives 75% of breast cancers. Stimulation of the ER by estra-2-diol forms a transcriptionally-active chromatin-bound complex. Previous studies reported that ER binding follows a cyclical pattern. However, most studies have been limited to individual ER target genes and w...

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Detalles Bibliográficos
Autores principales: Holding, Andrew N, Cullen, Amy E, Markowetz, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287946/
https://www.ncbi.nlm.nih.gov/pubmed/30457555
http://dx.doi.org/10.7554/eLife.40854

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287946/
https://www.ncbi.nlm.nih.gov/pubmed/30457555
http://dx.doi.org/10.7554/eLife.40854

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