Stress and interferon signalling-mediated apoptosis contributes to pleiotropic anticancer responses induced by targeting NGLY1

BACKGROUND: Although NGLY1 is known as a pivotal enzyme that catalyses the deglycosylation of denatured glycoproteins, information regarding the responses of human cancer and normal cells to NGLY1 suppression is limited. METHODS: We examined how NGLY1 expression affects viability, tumour growth, and...

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Detalles Bibliográficos
Autores principales: Zolekar, Ashwini, Lin, Victor. J. T., Mishra, Nigam M., Ho, Yin Ying, Hayatshahi, Hamed S., Parab, Abhishek, Sampat, Rohit, Liao, Xiaoyan, Hoffmann, Peter, Liu, Jin, Emmitte, Kyle A., Wang, Yu-Chieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288164/
https://www.ncbi.nlm.nih.gov/pubmed/30385822
http://dx.doi.org/10.1038/s41416-018-0265-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288164/
https://www.ncbi.nlm.nih.gov/pubmed/30385822
http://dx.doi.org/10.1038/s41416-018-0265-9

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