A Single H1 Promoter Can Drive Both Guide RNA and Endonuclease Expression in the CRISPR-Cas9 System

The RNA-guided endonuclease Cas9 (CRISPR-Cas9) genome editing system has been widely used for biomedical research and holds great potential for therapeutic applications in eukaryotes. The conventional vector-based CRISPR-Cas9 delivery system requires two different RNA polymerase promoters for expres...

Descripción completa

Detalles Bibliográficos
Autores principales: Gao, Zongliang, Herrera-Carrillo, Elena, Berkhout, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288460/
https://www.ncbi.nlm.nih.gov/pubmed/30530211
http://dx.doi.org/10.1016/j.omtn.2018.10.016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288460/
https://www.ncbi.nlm.nih.gov/pubmed/30530211
http://dx.doi.org/10.1016/j.omtn.2018.10.016

Ejemplares similares