Evidence for a protective role for the rs805305 single nucleotide polymorphism of dimethylarginine dimethylaminohydrolase 2 (DDAH2) in septic shock through the regulation of DDAH activity

BACKGROUND: Dimethylarginine dimethylaminohydrolase 2 (DDAH2) regulates the synthesis of nitric oxide (NO) through the metabolism of the endogenous inhibitor of nitric oxide synthase, asymmetric dimethylarginine (ADMA). Pilot studies have associated the rs805305 SNP of DDAH2 with ADMA concentrations...

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Detalles Bibliográficos
Autores principales: Lambden, Simon, Tomlinson, James, Piper, Sophie, Gordon, Anthony C., Leiper, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288902/
https://www.ncbi.nlm.nih.gov/pubmed/30538005
http://dx.doi.org/10.1186/s13054-018-2277-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288902/
https://www.ncbi.nlm.nih.gov/pubmed/30538005
http://dx.doi.org/10.1186/s13054-018-2277-5

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