Exploring the interaction between epidermal growth factor receptor tyrosine kinase and some of the synthesized inhibitors using combination of in-silico and in-vitro cytotoxicity methods

Quinazoline derivatives are potent inhibitors of human epidermal growth factor receptor (EGFR) as anticancer agents. In this study, the cytotoxic effects of a new series of synthesized quinazoline derivatives were evaluated using MTT assay against MCF-7 and HT-29 cell lines. Using molecular docking,...

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Detalles Bibliográficos
Autores principales: Nasab, Rezvan Rezaee, Mansourian, Mahboubeh, Hassanzadeh, Farshid, Shahlaei, Mohsen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288988/
https://www.ncbi.nlm.nih.gov/pubmed/30607149
http://dx.doi.org/10.4103/1735-5362.245963

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288988/
https://www.ncbi.nlm.nih.gov/pubmed/30607149
http://dx.doi.org/10.4103/1735-5362.245963

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