Deleterious mitochondrial DNA point mutations are overrepresented in Drosophila expressing a proofreading-defective DNA polymerase γ

Mitochondrial DNA (mtDNA) mutations cause severe maternally inherited syndromes and the accumulation of somatic mtDNA mutations is implicated in aging and common diseases. However, the mechanisms that influence the frequency and pathogenicity of mtDNA mutations are poorly understood. To address this...

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Detalles Bibliográficos
Autores principales: Samstag, Colby L., Hoekstra, Jake G., Huang, Chiu-Hui, Chaisson, Mark J., Youle, Richard J., Kennedy, Scott R., Pallanck, Leo J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289449/
https://www.ncbi.nlm.nih.gov/pubmed/30452458
http://dx.doi.org/10.1371/journal.pgen.1007805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289449/
https://www.ncbi.nlm.nih.gov/pubmed/30452458
http://dx.doi.org/10.1371/journal.pgen.1007805

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